Researcher - Protein Metrology

The job holder will help develop and validate analytical methods to support NML measurement research programmes for government. They will also assist private sector R&D contract commitments related to protein analysis. They must use advanced instruments and apply various sample preparation techniques as needed. The successful candidate will have experience in protein structural characterisation and, likely quantification by mass spectrometry. Training as needed will be provided on traceability of measurements to the System of International Units and on the instruments necessary for the delivery of the projects. This is an excellent opportunity for candidates seeking to advance their career in protein mass spectrometry. Key Responsibilities - Independent day-to-day planning and delivery of challenging research and development work, ensuring quality, timely delivery, and adherence to budget - Lead and manage protein and peptide metrology projects, concentrating on protein structural analysis through mass spectrometry - Publication and dissemination of scientific advancements and achievements - Provide support in formulating R&D commercial contracts - Build and nurture relationships with external partners and collaborators, and extend metrology networks to underpin the UK national measurement system - Delivery of ad-hoc research commercial projects and comprehensive reporting of results Knowledge, Experience and Technical Skills - PhD (or equivalent experience) in industry, academic, or clinical research - Demonstrated expertise in protein structure characterization methods involving mass spectrometry, such as HDX-MS, native MS, IMS, and XL-MS - Expertise in the development and optimisation of protein characterisation methods, particularly intact mass analysis and peptide mapping for the assessment of purity, homogeneity and stability - Experience on quantification approaches for peptides and proteins is highly desirable - Solid knowledge of protein chemistry and related workflows, encompassing peptide and protein sample preparation, treatment, and handling - Experience in peptide and protein separation and purification methods, including HPLC, SPE and dialysis - Proficiency in mass spectrometry instrumentation, operation and maintenance (e.g. Orbitrap and qTOF platforms including ion mobility applications) - Familiarity with bioinformatics tools and databases for protein identification and structural characterisation - Strong data analysis and interpretation skills, particularly for protein mass spectrometry data - Excellent written and verbal communication and presentation skills - Experience in managing and carrying out long-term and short-term research projects, adhering to deadlines, and producing high-quality technical reports Person Specification The role requires an enthusiastic scientist who will contribute to the successful delivery of analytical R&D projects. You are encouraged to share your achievements through relevant scientific publications, reports and presentations. The following person specifications are required: - Capacity to handle both extended and brief projects - Passionate and innovative scientist - Self-reliant and self-motivated great teammate - Excellent interpersonal skills - Strong attention to detail and a proactive attitude towards learning - Appreciation for working within a quality system and knowledge of good laboratory practice The job holder will be able to demonstrate the following behaviours in line with LGC’s values: Passion, Curiosity, Integrity, Brilliance, Respect