Parabilis Medicines

Independently design, optimize, execute, and troubleshoot cell-based assays to characterize and assess lead Helicons, including target engagement, potency, selectivity, mechanism of action, and differentiation...

Provide strategic leadership for peptide DMPK across multiple discovery programs, establishing ADME strategy and ensuring alignment with program milestones, development objectives, and broader portfolio priorities. ·...

Capture key biomarkers identified in preclinical studies and assess their feasibility for clinical translation, from pre-IND through Phase 1/2 programs · Develop or qualify and implement fit-for-purpose clinical...

Design, construct, and produce diverse mRNA display libraries using standard and advanced molecular biology techniques, including PCR, cloning, in vitro transcription/translation workflows, and chemical modification...

Lead Translational Data Science for preclinical Projects from target identification and credentialing through lead optimization. · Define computational strategies that address critical Project decisions around target...

Partner with business teams to map current-state workflows, surface the root causes of friction, and design cohesive future-state systems rather than incremental patches. · Own the architecture, workflow design, and...

Independently execute in vivo pharmacology studies supporting target validation, lead optimization, mechanism-of-action, and efficacy evaluation of Helicon therapeutics. · Perform mouse oncology studies using xenograft,...

Support corporate governance activities for a publicly traded company, including preparation of board and committee materials, resolutions, minutes, corporate records, entity management, corporate governance guidelines,...

Partner with the CEO and CFO to enhance and drive forward a strategic IR plan and strategy to effectively convey Parabilis’ story and value proposition to both the sell-side and buy-side with a goal of expanding the...

Lead drug design teams applying our AI design platform to facilitate rapid SAR decision-making, using state-of-the-art methods in medicinal chemistry and targeted protein degradation. · Serve as program leader, setting...

Implement, configure, and operate security controls across endpoint, identity, network, and cloud, including endpoint detection and response, managed detection and response, and software and extension controls. · Own...

Partner with discovery teams during Pre-LO/LO to identify safety liabilities, design early safety profiling studies, and guide candidate selection through science-based risk assessment. · Serve as the primary toxicology...

Design, execute, and troubleshoot phage display and mRNA display high-throughput screening campaigns to discover novel binders against challenging protein targets. · Design, construct, and produce diverse phage and mRNA...

Lead preparation of annual reports on Form 10-K, quarterly reports on Form 10-Q, and assist with other SEC filings (8-K, proxy statement, Form 4, S-8, S-1). · Manage draft review cycles across internal colleagues,...

Lead the development, optimization and implementation of high-throughput cellular and molecular assays across the biology team to advance early-stage programs. · Serve as a subject matter expert on target engagement and...

Build scalable New Product Planning capabilities and processes to support the company’s long-term growth · Lead New Product Planning activities for zolucatetide and future pipeline opportunities along with the team and...

Lead our early discovery portfolio (currently ramping up to 6 concurrent projects), providing scientific direction and support to teams and their leaders. · Work closely with company leadership on setting strategic...

Develop new assays: Design and validate fit-for-purpose biochemical and cell-based multiplexed assays that address emerging biological questions across the Helicon platform, taking them from concept to robust execution...

Design and execute target engagement and mechanism-of-action studies to characterize novel therapeutic candidates · Develop cell-based assays (e.g., NanoBRET, HiBiT, AlphaLISA, HTRF) from conceptualization and...

Project management of multiple late-stage Discovery programs through lead optimization to development candidate nomination. · Build and maintain integrated program timelines, track budgets, and manage resourcing...

Lead peptide DMPK strategy for discovery projects, aligning ADME objectives with project milestones and portfolio goals. · Design and interpret in vitro and in vivo ADME studies to inform lead optimization and DC...

Define and execute the Medical Affairs Oncology strategy aligned with the clinical development roadmap and portfolio priorities · Serve as a core member of the Development Leadership Team and contribute to broader...